Nova Norovirus study

Key Facts

Start date: November 20, 2025
25 months

Help to see if we can protect people against symptoms caused by the norovirus stomach bug with an investigational mRNA vaccine

The Royal Devon is looking for participants for the Nova 301 Trial. This trial will see if an investigational vaccine can protect people 60 years of age or older against symptoms caused by the norovirus stomach bug.

About the norovirus stomach bug 

Norovirus is one of the most common stomach bugs in the UK.1 It can spread easily and most cases are often in care homes and schools.2 The norovirus stomach bug can cause many unpleasant symptoms like nausea, vomiting, and diarrhoea.1 Vulnerable people, such as children younger than age 5, adults older than age 60, and people with underlying health conditions, are at greater risk for serious symptoms of norovirus, which may require medical attention.3,4

The Nova 301 Trial will see if an investigational vaccine (a vaccine that is being studied) may be able to prevent symptoms caused by the norovirus stomach bug from developing in people 60 years of age or older. The investigational vaccine in this clinical trial is called mRNA-1403. You cannot catch norovirus by having this investigational vaccine.

Who can join?

To join, you must: 

  • Be 60 years of age or older
  • Be in good health
  • Not currently have a chronic gastrointestinal disease (including irritable bowel syndrome, colitis, oesophageal reflux, or any other medical condition where you have regular vomiting or diarrhoea)

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Who’s Involved

Partners

Delivered by South West NHS Partners

Our research is supported by an experienced network of NHS Trusts across the South West, helping ensure each study is delivered with care, precision, and integrity. Participating sites include:

Link to The Royal Devon University Healthcare NHS Foundation Trust

Enquiries